Aiming at the unclear issue of damage accumulation and evolution related to the stress state of explosive charge during multiple penetration processes， this study employs a micro-crack and micro-void macro-meso damage model for PBX explosives， combined with an interface cohesion damage model. It comprehensively considers various micro-defect damage mechanisms， including the opening and shear propagation of microcracks in explosive particles， the expansion and distortion of microvoids in the matrix， as well as interface cracking and tearing damage. The stress states and micro-defect accumulation and evolution of a penetration warhead charge during penetration of a ten-layer concrete target at different impact angles are comparatively analyzed. The results indicate that during multiple penetrations， the charge experiences cyclic pulse loading. The deflection of the projectile attitude （from 10° to 44°） shifts the loading mode from predominantly axial compression to tangential shear， inducing abrupt changes in local pressure peaks （from 50 to 220 MPa） and significant increases in shear stress， thereby accelerating damage accumulation. Microcrack and interface damage within the charge initially initiate at the head edge region， propagate to the tail during stages of pronounced attitude deflection， and eventually， opening-mode cracks develop in the middle section of the charge due to bending effects. An increased impact angle （from 0° to 10°） intensifies the internal shear action on the charge， extending microcrack damage towards the middle and rear sections， enhancing microvoid distortion damage， and transitioning interface damage from early-stage opening-dominated to late-stage shear-dominated behavior. The simulated damage distribution and morphological characteristics are in good agreement with experimental CT images， validating the effectiveness of the proposed model. The findings provide theoretical support for deepening the understanding of damage accumulation and stability degradation mechanisms of charges under multiple penetrations， and for advancing the digital design capability of penetration stability.