To supplement the scarce basic solubility data of cyclotetramethylene tetranitramine （HMX） in dimethyl sulfoxide （DMSO）-alcohol mixed solvent systems and solve the technical bottleneck restricting the optimization of HMX crystallization process， the solubility of HMX in three binary mixed solvents of DMSO-methanol， DMSO-ethanol and DMSO-n-propanol was measured via the static method within the temperature range of 293.15-343.15 K. The experimental solubility data were correlated and fitted by the Apelblat model， Jouyban-Acree model and NRTL model， and the dissolution thermodynamic properties of HMX were further calculated and analyzed based on the NRTL model. The results show that the solubility of HMX in the three mixed solvent systems increases significantly with the rise of temperature and DMSO mole concentration. The Apelblat model exhibits the optimal correlation performance for the solubility data of the systems， with the average relative deviation （ARD） less than 5% and the root-mean-square deviation （RMSD） less than 0.11%， which is superior to the other two models. Thermodynamic analysis indicates that the dissolution process of HMX in all three DMSO-alcohol mixed solvent systems is endothermic， entropy-driven and spontaneous.