To enhance the thermal safety of microreactors utilized for preparing energetic materials， a computational fluid dynamics simulation based on the finite volume method was employed to investigate the impact of structural parameters on flow and heat transfer in a spiral microreactor. The findings reveal that centrifugal force induces continuous directional secondary flow disturbance within the spiral channel， thereby augmenting fluid heat transfer performance. Increasing the curvature of the spiral microreactor， reducing the dimensionless pitch value， and elevating fluid velocity effectively enhance Nusselt number while controlling drag coefficient along the reactor path. Notably， scaling up beyond a radius of 2.5 mm leads to a significant decline in heat transfer performance of a spiral microreactor exhibits a scale-up effect， with a significant decrease in heat transfer performance for spiral microreactors. By maintaining a controlled radius at 2.5 mm， high heat transfer performance can be sustained even with a 25 times increase in heat transfer fluid flux and an impressive 98.9% reduction in pressure drop.