The safety issues of weapons and ammunition are essential that they matter the survivability and effectiveness of weaponry. The complex and harsh enviroments faced by ammunition lead to the high requirment of ammunition safety that the development of safe ammunition is the only way. Ammunition safety mainly depends on inherent safety and safety enhancement technology. Using insensitive explosives is the key way to improve the inherent safety of ammunition， while the enhancement and protection of charge and structure are important means to improve ammunition safety . In order to meet the requirements of high damage power and safety of ammunition， it is necessary to balance and coordinate the prominent contradiction between high energy and insensitivity of explosives from the multi-scale structures， such as molecules， crystals and mixed systems of explosives. Safety enhancement technologies such as charge structures， weak link structurse of projectiles and protection enhancements can effectively control the accidental ignition， reaction violence and evolution ammunition charges， and furthermore improve the safety of ammunition under abnormal environment and accident conditions. Therefore， the design ideas and technicalapproches for safety ammunition systems were proposed， including strengthening the foundation of multi-scale material design and performance control of insensitive explosives， complementing the shortcomings of charge structures， protection enhancement， and accidental ignition and reaction control， and exploring and developing the integrated design of material，- structure- and function .