In order to increase the density and detonation energy of the explosive， hydroxyl-terminated fluorine-containing binder （HTFB， 1.40 g·cm^-3） was applied to the formulation of casting PBX explosive （polymer bonded explosive）. The effects of toluene diisocyanate （TDI）， isophorone diisocyanate （IPDI）， hexamethylene diisocyanate （HDI） and hexamethylene diisocyanate trimer （3HDI） on the viscosity and curing process of the binder system were studied， and the effects of curing agents on curing and mechanical properties were also investigated. Results show that the curing agent can significantly reduce the viscosity of the binder system. In the temperature range of 25-70 ℃， the higher the temperature， the lower the viscosity of the binder system was. Above 60 ℃， the viscosity of HTFB binder system changed gently and the difference of each system was small. As curing agent， the viscosity， opening time and gel time of trifunctional isocyanate are more suitable for the preparation process of casting PBX explosive. Based on the formulation of aluminum-containing casting explosive with 88% solid content and the preparation process of pinch-vacuum injection-curing， the influence of HTFB binder on the preparation process and properties of explosive was studied in comparison with HTPB. The HTFB based PBX explosive show decent casting rheological properties and curing quality， and the density and detonation heat are 1.96 g·cm^-3 and 7790 J·g^-1， which are 6.52% and 6.55% higher than that of HTPB based PBX explosive， respectively.