This review summarized progress of 2，4，6-trinitrotoluene （TNT） multifarious reutilization in the aspects of chemical transformation and microorganism degradation. Chemical transformation pathways are classified into TNT methyl oxidation， nitro reduction， and substitution reaction. The diverse chemical transformation pathways were systematically summarized according to the green environmental protection， reaction mechanism， reaction efficiency and product properties combined with resource reuse. The microorganism transformation pathways are classified into aerobic bacteria， anaerobic bacteria and fungus. A more comprehensive overview of the aerobic and anaerobic metabolic pathways of TNT microorganisms is presented， summarizing the relevant microorganisms. Finally， the development direction of waste TNT resourceful reuse based on chemical and biological transformation is prospected. Chemical transformation of TNT will go beyond the laboratory research stage， and green process research and safety will be the focus of this stage of research. Microbial transformation of TNT remains the focus of research， and combined with genetic engineering and modern molecular biology technology， it is expected to provide new solutions for deep reuse of waste TNT.