To control the morphology， particle size distribution and coating covering effect of high polymer binder explosives （PBXs）， TATB/F2602 microspheres could be prepared via high sensitivity droplet microfluidic technology， and investigated the effects of binder content and flow rate on the morphology and particle size of TATB-based microspheres. Moreover， it studied the morphology， structure， composition and thermal behavior of microsphere samples systematically using scanning electron microscopy， X-ray diffraction， specific surface area， DSC and TG， respectively. Results show that， when the binder content is 5%， the microspheres have smooth surfaces， regular spherical shapes and high spherical monodispersity， and the average roundness is 0.921 （span=0.04）. With the increase of flow ratio， the D₅₀ of microsphere sample decreased from 51.73 to 44.31 μm， and the particle size distribution is narrow （span<0.4）. Fluororubber （F2602） is uniformly distributed in the interior and surface of TATB microspheres， and uniform coating of TATB particles delay the thermal decomposition of microspheres by 4.08 ℃. Compared with raw TATB， the true density of TATB/F2602 increases to 1.9780 g∙cm^-3 during spheroidization. The droplet microfluidic technology can effectively control the morphology and particle size of explosive microspheres， and provide experimental reference for the spherical preparation of polymer bonded explosives.