To facilitate the crystallization of spherical FOX-7, a laser dynamic method was performed to determine the solubility of FOX-7 in the solvent mixtures of DMSO-EAC with different volume ratio in the temperature range of 298.15~333.15 K. The solubility equation was established and the crystallization thermodynamic parameters were estimated. The cooling crystallization experiment was carried out in DMSO-EAC mixed solvent. The results show that the solubility of FOX-7 in mixed solvents increases with increasing temperature and DMSO content. All models fit well with experimental data, of which the CNIBS/R-K model has the best correlation. The crystals of FOX-7 obtained by cooling crystallization in V_DMSO∶V_EAC=1∶3 system are regular, ellipsoidal and uniform in particle size.