To improve its thermal safety, the effects of lead and copper salt catalysts, including CuSa, PbSa,β-Cu, Cu(PA)₂, and CuO , on thermal decomposition and cook-off responses of DNTF were studied through PDSC and small scale cook-off experiments. Experiment results show that the thermal decomposition and cook-off reaction level can be adjusted by different analysts. To be specific, the organic copper salts, i.e., CuSa, β-Cu and Cu(PA)₂, increase the rate of thermal decomposition of DNTF while reduce the decomposition temperature of DNTF. PbSa increases the decomposition temperature of DNTF by 3.1 ℃ and promotes its second decomposition; CuO has no effect on the thermal decomposition of DNTF. CuSa decreases the response temperature of cook-off test at heating rate of 1 ℃·min^-1 for unrestrained DNTF from 236.6 ℃ to 182.3 ℃ while for high constraint by 2.4 ℃, and changes the reaction levels of both unrestrained and high constrained from explosion to burning. This implies that the cook-off responses of DNTF-based explosive could be decreased by organic copper salts, such as CuSa.