The synthesis of novel high energy low sensitivity materials is important for improving of energy level and safety performance of weapons. 5,6-Diaminofurazano[3,4-b]pyrazine-4,7-dioxide (DAFPO) was firstly synthesized by oxidation reaction using 5,6-diaminofurazano[3,4-b]pyrazine as raw material. Its structure was characterized by nuclear magnetic resonance (¹H, ¹³C and ¹⁴N spectrum), infrared spectroscopy and element analysis. The single crystal of DAFPO·2H₂O was cultivated from ethyl acetate. Its crystal structure was determined by X-ray single-crystal diffraction, and the intermolecular interactions were investigated by Hirshfeld surface analysis. DAFPO·2H₂O belongs to orthorhombic system, space group Pna2₁, the crystal density is 1.806 g·cm^-3 at 296 K. The crystal is stabilized by strong O…H and N…H hydrogen bonds interactions existed in different molecules. The thermal behavior of DAFPO was studied by DSC and TG/DTG method, giving decomposition temperature at 131.8 ℃. Based on atomization reaction and Gaussian 09 software, the calculated solid heats of formation of DAFPO is 753.5 kJ·mol^-1. Its density is 1.86 g·cm^-3 by gas expansion replacement method. The calculated detonation velocity and detonation pressure predicted by EXPLO5 code are 8836 m·s^-1 and 36.0 GPa, respectively. According to standard BAM method, the impact sensitivity is above 40 J, and the friction sensitivity is above 360 N. It is found that DAFPO is a novel low sensitivity energetic material with high energy level and good safety performance.