To determine the influence of various factors in the production process of solid propellant on the friction sensitivity, the response surface methodology (RSM) combined with central composite design (CCD) was used to design the experiments based on the pendulum angle, the strut pressure and the sample temperature were taken as influencing factors, and the friction sensitivity value of solid propellant was considered as the response value. The friction sensitivity tester was used to test and analyze, the testing results were fitted to the response surface model. Results show that in three response surface evaluation accuracy indexes, the relative root mean square error RMSE is 0.14, the determination coefficient R² is 0.9309, and the correction fitting degree is 0.8686, showing that the fitting precision of the equation is high and the error is small. The variance ratio F obtained by variance analysis of the model is 14.96, indicating that the model has a higher influence on the response surface. The probability value p is 0.0001, indicating that the probability of 0.01% of the model has no effect on the response surface. The response surface map shows the interaction between the various factors. The three-factor operating range corresponding to the minimum friction sensitivity value obtained by the model optimization is less than 45° in angle, less than 2 MPa in pressure, and less than 45 ℃ in temperature.