To solve the flammable and combustible problem of discarded isopropyl nitrate, the hydrolysis of isopropyl nitrate was catalyzed by sodium hydroxide. The hydrolysis effect of isopropyl nitrate was detected by coupling gas chromatograph and mass spectrometer(GC/MS). Effects of reaction temperature, reactant ratio, catalyst dosage and reaction time on the conversion rate of isopropyl nitrate were discussed by orthogonal test. Results reveal that, the gas phase hydrolysis of isopropyl nitrate under high temperature and high pressure can greatly increase the hydrolysis rate constant and accelerate the hydrolysis reaction. The optimum process conditions for hydrolysis of isopropyl nitrate are determined as follows:reaction temperature 140 ℃, V(isopropyl nitrate):V(water) =1:3, n(isopropyl nitrate):n(sodium hydroxide) =1:1.1, reaction time 30 min. The hydrolysis conversion rate of isopropyl nitrate can reach 99% and the hydrolysis is more thorough. The yield of isopropyl alcohol is 70%-80%.