Aiming at the problem that in the degradation of phenol wastewater by Electro-Fenton, Fe of Fe anode is easily dissolved, which affects the degradation efficiency, the study on the degradation of phenol wastewater by Electro-Fenton was carried out using ghe dimensionally stable anode of Ti/IrO₂-Ta₂O₅. The degradation intermediate products and degradation process of phenol wastewater of Ti/IrO₂-Ta₂O₅ anode and Fe anode for Fenton degradation of phenol were detected by high performance liquid chromatography(HPLC). Results show that when FeSO₄·7H₂O dosage is 0.1 g·L^-1, H₂O₂ dosage is 2.94 mmoL·L^-1, initial pH is 3.5, voltage is 5 V and degradation time is 2 min, by using Ti/IrO₂-Ta₂O₅ anode, the removal efficiency of phenol and COD can reach 94.14% and 40.74%, respectively. When Fe anode is used, at the same initial pH, voltage and degradation time, the removal efficiencies of phenol and COD are 40.74% and 26.41%, respectively. Compared with the Electro-Fenton process of Fe anode, the Electro-Fenton method of Ti/IrO₂-Ta₂O₅ anode has the advantages of less acid consumption, less H₂O₂ dosage, shorter reaction time, lower electrolysis votage, lower consumption of electrode and better treatment effect for degradating phenol wastewater. The degradation process of phenol wastewater of Ti/IrO₂-Ta₂O₅ anode and Fe anode for Fenton degradation of phenol are the same, but the degradation efficiency of phenol wastewater by Electro-Fenton method with Ti/IrO₂-Ta₂O₅ anode is higher in the same degradation time. This is because the electrocatalysis reaction using Ti/IrO₂-Ta₂O₅ anod and Electro-Fenton reaction can form a synergisic effect, the synergistic degradation of wastewater is more than that of alone Electro-Fenton reaction using Fe anode.