1, 2, 4-Oxadiazoles are a new class of energetic materials, which have the features of high density, high oxygen balance and insensitivity. In this paper, the latest organic synthesis achievements of more than 30 oxadiazole energetic compounds base on mono-1, 2, 4-oxadiazoles, azo-1, 2, 4-oxadiazoles and bis-1, 2, 4-oxadiazoles were reviewed, and their performances were also introduced in detail. 1, 2, 4-oxadiazoles would be new choice as chlorine-free oxidizers due to its advantages.