Aluminum foams are multifunctional materials possessing excellent energy absorption properties, and the sandwich composed of multi-layers aluminum foam and steel panels possesses excellent resisting blast ability.In order to study the effect of arrangement sequence of aluminum foam with different densities on the resisting blast ability of sandwich panels, the three aluminum foams which relative densities were 13.0%, 16.7%, 20.4% respectively were selected to compose nine kinds of arrangement modes with different structures. The numerical simulation of blasting process was performed by LS-DYNA softwar, the blast action experiments for parts of the structure were carried out. The results show that the results of experiment and simulation are in accordance with each other. Under the action of blast loading, the deformation of aluminum foam can be divided into three kinds of modes, namely elastic deformation, plastic deformation and densification deformation with cell wall rupture. Transverse deflection of the baseplate of aluminum foam density decreasing structure is smaller than that of the baseplate of aluminum foam density increasing structure, and the trasmission wave strength of aluminum foam density decreasing structure is only 31.6% of the density increasing structure under the same blast loading action, which indicates that the aluminum foam arranged in order of density decreasing can improve the blast-resistance ability of the whole structure.