To obtain the initiation respone rule of explosive compound under the action of plasma, the plasma initiation experiments of explosive compound were performed using electrical exploding of nickel-chromium (Ni-Cr) and tungsten (W) wires as a plasma generating source, the voltage and current of plasma were measured by oscilloscope, and whether explosive detonation was judged by witness plates. Results show that the ability of octogen (HMX) initiated by Ni-Cr wire plasma is stronger than that of HMX nitiated by W wire plasma. When the initiation of HMX with particle size of 140 μm and 21 μm and of 10% charge density difference is selected, and lower charge density and smaller particle size are used, the plasma initiation respone of HMX is more intense. HMX, 1, 1-diamino-2, 2-dinitroethylene (FOX-7), N-guanylureadinitramide (FOX-12), 2, 6-diamino-3, 5-dinitropyrazine-1-oxide (LLM-105) and triaminotrinitrobenzene (TATB) can be initiated by plasma. 2, 4-dinitroanisole (DNAN) is ignited by heat of electrical exploding wire. The order of Ni-Cr wire plasma initiation sensitivity is HMX>LLM-105≈FOX7>FOX-12>TATB. The mechanism of explosive initiated by plasma is inferred as mixed initiation mechanism. A particles combustion model based on plasma is proposed.