To select the energetic plasticizer which is compatible with 3, 3-bis (azido methyl) oxetane (BAMO) and tetrahydroxyl furan (THF) copolymer (PBT) and has low glass-transition temperatures of the mixture with PBT, the compatibilities between PBT and five kinds of energetic plasticizers, triethyleneglycol dinitrate (TEGDN), 1, 3-diazido-2-ethyl-2-nitropropane (DAENP), N-butyl nitroxyethyl nitramine (Bu-NENA), 1-allyl-3, 4-dinitropyrazole (ADNP), bis (2, 2-dinitropropyl) formal and bis (2, 2-dinitropropyl) formal acetal mixture (mass ratio of BDNPF/A is 1:1, A3), and glass-transition temperatures of PBT plasticizer blends were simulated and studied by means of MD method. The reasons of the interaction between PBT binder and energetic plasticizer were analyzed. Results show that the compatibility order of PBT and energetic plasticizer is Bu-NENA > DAENP > A3 > TEGDN > ANDP, TEGDN and ANDP are incompatible with PBT. The order of glass transition temperatures of the PBT and plasticizer mixture is PBT/Bu-NENA < PBT/TEGDN < PBT/DAENP < PBT/ADNP < PBT/A3. The compatibility between Bu-NENA and DAENP and PBT is better compared with the existing PBT plasticizer A3 and the glass transition temperatures of the PBT/Bu-NENA and PBT/DAENP mixed system are lower