Halogenated adamantine derivatives are widely applied in the field of medicinal chemist, polymer and energetic materials as organic chemical intermediates. This review is intended to provide the synthetic methods of halogenated adamantine compounds, including 1-fluoroadamantane, 1-chloroadamantane, 1, 3, 5, 7-tetrachloroadamantane, 3-chloroadamantane-1-carboxylic acid, 3, 5-dichloroadamantane-1-carboxylic acid, octachloroadamantane-1-carboxylic acid, 1-bromoadamantane, 1, 3-dibromoadamantane, 1, 3, 5, 7-tetrabromoadamantane, 1-iodoadamantane and 1, 3, 5, 7-tetraiodoadamantane. It is worthy of further research, which includes the purification and separation process of polyhaloadamantane, new synthesis routes of halogenated adamantine with more than eight halogen atomes and new green reagents and catalysts.