Nanothermites can be used as the propellant of MEMS-based microthrusters. Addition of energetic binder can enhance the propulsion performance of nanothermite. In this work, nitrocellulose(NC) and polyvinylidene fluoride(PVDF) were chosen as the binder, and the mixtures were prepared by electrospray mixing process. Based on both Chemical Equilibrium and Application(CEA) software calculation and experiments, the influences of fuel/oxide equilibrium ratio (ϕ) and the content of binding agents on propulsion performance were systematically studied, while the results were compared with propulsion performance of the mechanically mixed nanothermites. Results show that nanoparticles were more uniformly dispersed in the electrospray mixed nanothermite than the mechanically mixing case. The calculated optimum ϕ of Al/CuO was 0.9, while the optimal tested ϕ was 1.8. Specific impulse of the mixture reaches 250.2 m·s^-1, by increase of 8.0% for 2.5% NC in comparison with the binder-free Al/CuO. The addition of PVDF reduces the tested specific impulse. The decomposition products of binder separate nanoparticles and increase the characteristic mass transport length of the condensed phase reaction, leading to a distinctly increase in combustion duration, from 2.9 ms to 87.8 ms.