To optimize the performance of the detonation wave aiming warhead, the different forms of asymmetrical initiations were studied. The fluid dynamic simulation model verified by experiment was used to research the effects of asymmetrical one initiation line with different initiation points, asymmetrical two initiation lines with different central angles, and the asymmetrical three initiation lines with different central angles of the adjacent lines on warhead fragment velocity and scattering. The results show that for the researched object, 4 initiation points are adequate in one initiation line; in the asymmetrical two lines initiation, the central angle of 60° may produce the highest velocity enhancement 38.37% in the aiming direction side, so do the asymmetrical three initiation lines with central angle of 45°, with an enhancement of 39.36%. The velocity enhancement of the fragments in the aiming direction is the interacting results of detonation transfer length (time) and the detonation pressure.