A novel acidic ionic liquid(ILs), 1-dodecyl-3-(3-sulfopropyl)-imidazolium hydrogen sulfate [C₃SO₃HDoim]HSO₄ was designed and synthesized, and used for condensation reaction of aldehyde and amine to synthesize the energetic material intermediates. Taking the synthesis of tetrahydroimidazo[4, 5-d]imidazol-e-2, 5-(1H, 3H)-dione, 2, 5, 7, 9-tetrazobicyclo[4,3,0]nonan-8-one and hexabenzylhexaazaisowurtzitane (HBIW) as the example, the influences of reaction temperature, reaction time, amount of ILs and types of ILs on condensation reaction were investigated. Results show that ILs [C₃SO₃HDoim]HSO₄ has good catalytic activity, high cyclic utilization reusability and the yields of three kinds of multi-nitrogen heterocyclic compounds glycoluril, 2, 5, 7, 9-tetrazobicyclo[4,3,0]nonan-8-one and HBIW, can reach 95%, 89% and 81%, respectively.