The interaction and compatibility of N-oxidiation-3,3′-azobis(6-diamino-1,2,4,5-tetrazine) (DAATO_3.5) with main components of modified composite double-base(CMDB)propellant were studied by using differential scanning calorimetry(DSC) and vacuum stability test(VST)method,and the compatibility of DAATO_3.5 with mixture system of CMDB propellant was investigated by curing experiment of propellant at 70 ℃. DSC results show that there are no obvious interaction between DAATO_3.5 with nitrocellulose (NC),nitroglycerine (NG),cyclotetramethylenete-tranitramine (HMX),3,4-dinitrofurazano-furoxan (DNTF),aluminum powder (Al),N-nitrodihydroxyethylaminedinitrate (DINA),carbon black (C.B) and 1,3-dimethyl-1,3-diphenylurea (C₂). There are obvious interaction between DAATO_3.5 with cyclotrimethylene-trinitramine (RDX),hexanitrohexaazaiso -wurtzitane (CL-20) and resorcinol (Res). Res is found no influence on peak temperature but can obviously change the peak profile of DAATO_3.5. Ammonium perchlorate (AP) has no interaction with DAATO_3.5,while DAATO_3.5 can remarkably decrease the onset temperature of AP from 310 ℃ to 275 ℃ and make the double decomposition peak of AP merge into one decomposition peak,with the decomposition peak temperature decreasing 52.9 ℃ than the high decomposition peak temperature of AP. VST results show that DAATO_3.5 with AP is compatible,with Res is incompatible and with RDX have moderate reaction. It was experimentally show that DAATO_3.5/CMDB propellant could be safety preparated uniformly and compactly at 70 ℃. It can be concluded that DAATO_3.5 may be applied to CMDB propellant.