To study the effect of loading ratio of thermobaric charge on the damage power of warhead,the experimental study on formation products and energy output characteristics after explosion of 30 kg thermobaric charge composed of 65% HMX and 35% high activity grading Al powder as main components was carried out. According to test results,the mathematical calculation model of characterizing the total energy and total specific impulse of thermobaric warhead damage power was set up. With the help of results obtained by static explosive test from the ground 1.5 m of a 200 kg thermobaric warhead with 70 kg thermobaric charge,the overpressure and specific impulse of shock wave at different distance to the explosion center were calculated using the obtained mathematical model. Results show that the calculated and the experimental results have good consistency,which proves correctness of the mathematical model. The changes in total specific impulse at different distance to the explosion center for the 200 kg thermobaric warhead with different loading ratio were calculated,indicating that the specific total impulse and damage power has a maximum value when the loading ratio is 40%.