The simulation of detonation wave pressure of the three-point, four-point, six-point, eight-point synchronization detonation for slapper detonators were performed respectively by the finite element program AUTODYN software.The factors affecting the detonation wave pressure of multi-point synchronization detonation were analyzed.The detonation wave pressure of multi-point synchronization initiation for slapper detonators was measured by a Manganese Bronze manometry.The action process of four-point synchronization slapper detonators were filmed by a high speed photography system.Results show that a four-point detonation slapper detonators overpressure relative to the average of three-point, six-point, and eight-point is the highest; in the center distance of 4 mm and the same loading dose of 180 mg, the detonation wave generated by four initiation points occurs the collision with each other, and the detonation wave superposition forms overpressure detonation, and can reliably detonate insensitive explosive TATB.In the center distance of 8 mm and the same loading dose of 180 mg, due to center distance is far, detonation wave attenuation is faster, adjacent points detonation wave collision happened is less, the overpressure produced also decreases.