In order to develop new nitratopolyether binders, 2-nitratomethyltetrahydrofuran(NMTHF) was synthesized with 2-hydroxymethyltetrahydrofuran(HMTHF) as starting material and dinitrogen pentoxide(N₂O₅) as nitrating agent with yield of 90.6% and purity of 98.9%.The structure of NMTHF was characterized by IR, ¹H NMR and element analysis. The effects of synthetic conditions on nitration reaction were discussed.The optimized synthetic conditions are as follows:n(N₂O₅):n(HMTHF)=1.0:1.0, reaction temperature -10 ℃, and keeping reaction for only 5 min when the CH₂Cl₂ solvent of HMTHF was dropped over.