The launch safety of RDX-based aluminized explosive(R-Al explosive) was studied by 400 kg large drop hammer experiment and one-stage light-gas gun experiment. The stress-time curves of the explosive charge were obtained under the two different experimental conditions. Comparison of the launch safety of R-Al explosive and casting Comp.B was carried out. Results show that the ignition of R-Al explosive does not occur under the conditions of loading stress of 1.47 GPa and loading time of 3.04 ms for large drop hammer and loading stress of 660 MPa and loading time of 41 μs for one-stage light-gas gun. The ignition of casting Comp.B does occur under the conditions of loading stress of 840 MPa, loading time of 2.10 ms for large drop hammer and loading stress of 394 MPa, loading time of 40 μs for one-stage light-gas gun, revealing that the launch safety of R-Al explosive is better than that of casting Comp.B.