In laser-driven flyer technology, the efficiency of laser and the velocity of flyers can be improved by the using of multi-flyers. In order to obtain the influence of each layer in multi-flyer with different materials and thickness on the velocity of flyers, multi-flyers with different parameters were prepared by Ti, C, Al₂O₃ and Al. The multi-flyers were driven by Neodymium-Yttrium-Aluminium Garnet-Laser laser system in the energy range between 200 mJ and 300 mJ. The velocity of multi-flyers were tested by Photonic Doppler Velocimetry (PDV). Results show that the velocity of multi-flyers with absorption layer (0.15 μm, Ti) increases 110% compared to single flyer, and the velocity of multi-flyer with insulation layer(0.3 μm, Al) and ablation layer(1.0 μm, Al₂O₃) increases 41% compared to single flyer. Energy utilization and accelerate distance of different multi-flyers were analyzed. It indicates that the velocity of laser-driven multi-flyers can reach 90% of maximum velocity at 0.02 μs, and reach a maximum at 0.08 μs.