Six difurazanopyrazine derivatives (Ⅰ~Ⅵ) were synthesized using 4H, 8H-difurazano[3, 4-b:3′, 4′-e]pyrazine(DFP) as starting material, via salification, substitution, addition, nitration, chlorination and azidation reaction, and their structures were characterized by IR, NMR, and elemental analysis. Using compound Ⅱ, Ⅳ, Ⅵ with nitrofurazan, ntriateester, azide group as typical one, the thermal performances were studied by differential scanning calorimetry(DSC) and thermogravimetric(TG), and the physical and chemical properties were calculated by Gaussian 09, and the detonation performance by VLW. Results show that the three compounds have good thermal stability with thermal decomposition temperature of 318.3, 197.5 ℃, and 250.5 ℃, respectively. The density, detonation velocity and detonation pressure of compound Ⅳ are 2.0 g·cm^-3, 9067 m·s^-1 and 43 GPa, respectively. Compared with HMX, compound Ⅳ exhibits similar detonation velocity, higher density and detonation pressure.