Using 2-choro-4-aminopyridine as primary material, a new compound 7-amino-6-nitro-[1,2,5]oxadiazolo[3, 4-b]pyridine 1-oxide was synthesized by nitration, azide substitution and cyclization reaction with a total yield of 42%, and its structure was confirmed by ¹H NMR, ¹³C NMR, IR, MS and elemental analysis.Friction and impact sensitivities of the title compound obtained by GJB772A-1997 are 0 and the decomposition temperature is 215.93 ℃.Results show that 7-amino-6-nitro-[1,2,5]oxadiazolo[3, 4-b]pyridine 1-oxide is a low sensitivity energetic material.