In order to study the influence of the reinforced concrete target(RC) thickness on penetrator with enhanced lateral effect(PELE)penetrating, the different thickness RC impacted with the velocity of 800 m·s^-1 was simulated by LS-DYNA 3D software. Results show that PELE can penetrate the 80 cm thickness target at large. In this range, PELE body shell residual length is shorter with the target getting thicker when PELE could penetrate the targets, and the residual axial velocity of PELE decreases at the same time. With increase of target thickness, the undermining effect of penetration first increases, then decreases. The kinetic energy consumes totally in the penetration process when the targets thickness is over 80 cm. The experiment was carried to verify the simulation results. The experimental and simulated results both show that the 35 cm thickness target is damaged most severely, implying that the simulation are correct and reliable.