To analyze the effects of component and proportion of composite binder on the interfacial interaction of polymer bonded explosive (PBX), based on different theoretical models, the interfacial interaction between fluoropolymer F2314/acrylonitrile-styrene copolymer (AS) composite and 1, 3, 5-triamino-2, 4, 6-trinitrobenzene (TATB) was evaluated using multiple parameters (parameters A、β and effective volume fraction φ_e). Results show that the interfacial interaction between F2314/AS composite binder and TATB is related to phase transition of F2314 and AS, with a fluctuation as temperature increases. The values of interfacial interaction parameter β of TATB/F2314 composite and TATB/AS composite are 0.969 and 0.840, respectively. With the F2314 content increasing at 20 ℃, the effective volume fraction φ_e of explosive particles and the relative value of the effective volume per single particle B increase, and the interfacial interaction between explosive particles and composite binders in PBX can be enhanced.