The synthesis of cyclourea nitro-amine energetic compounds is reviewed. Two synthetic methods of cyclourea nitro-amine derivatives through urea condensation-nitration method or small molecule condensation-nitration method are summarized. Compared to other energetic compounds, the characteristics of N-dinitro-substituted cyclourea nitro-amine derivatives have high density, high detonation velocity and poor hydrolytic stability, and possible reasons for these performances are preliminarily discussed. Their importance in energetic materials are revealed.