To study the dynamic responses of armored vehicle to explosive loading, three-dimensional simulation of an armored vehicle model composed of 4340 steel and rubber was performed by an AUTODYN software. The explosion process of 8701 explosive with different charge mass condition was calculated. The response parameters of three observation points on the side of steel plate such as overpressure, displacement and acceleration were obtained. The regularity of dynamic response for the observation points was analyzed. Results show that the closer from the explosion source location or the greater the loading charge, the earlier the response time of the vehicles, the more intense the node oscillation, the larger the oscillation amplitude and the shorter the duration.