In order to reduce the manufactur costs of 1-oxide-2, 6-diamino-3, 5-dinitropyrazine(LLM-105), LLM-105 was synthesized using 2, 6-diamino-3, 5-dinitropyrazine(ANPZ) as staring material and high concentration hydrogen peroxide(H₂O₂) solution as oxidizing agent. The effect of 50% and 85% concentration of H₂O₂ on the oxidation reaction of LLM-105 was discussed. Trifluoroacetic acid (TFA) used was reduced 50% compared with the original method. The synthetic technology of LLM-105 oxidation was optimized by an orthogonal test. The optimum processing conditions were determined as: n(ANPZ):n(50%H₂O₂)=1:6, m(ANPZ):V(TFA)=1:5(g:mL), reaction temperature 25~30 ℃ and reaction time 24 h. The yield of LLM-105 is 95% and the purity 98%.Its structure was characterized by IR spectrometry, elemental analysis, NMR spectrometry and MS.