Tetrazine 1,3-dioxide is a potential energetic moiety in the design and synthesis of high energy density materials. The synthetic methods of 1,2,3,4-tetrazine 1,3-dioxide and its key intermediate 2-tert-butyldiazene oxide were reviewed respectively, and the research progresses in benzo-1,2,3,4-tetrazine 1,3-dioxide, pyrido-1,2,3,4-tetrazine 1,3-dioxide, nonannulated 1,2,3,4-tetrazine 1,3-dioxides and their derivatives were reviewed in detail. Moreover, the development progress of furazano［3,4-e］-1,2,3,4-tetrazine 4,6-dioxide (FTDO) and 1,2,3,4-tetrazino［5,6-e］-1,2,3,4-tetrazine 1,3,5,7-tetraoxide(TTTO), two typically energetic materials, was presented. 