The strategies, methods, paths, characters, starting materials and nitrating systems of synthesizing 2, 4, 6-trinitro-2, 4, 6-triazacyclohexanone(Keto-RDX) were summarized, analysized and reviewed with 22 references. Considering that direct method using urotropine and urea as starting materials has the advantages of less steps, lower cost and higher yield and the disadvantages of difficult separation and purification from a mixtures of Keto-RDX and RDX, while the multistep method of synthesizing Keto-RDX via 1, 3, 5-triazine intermediates has the disadvantages of more reaction steps and higher cost and the advantages of easier separation and purification.