According to combustion theory and chemical structure of o-chlorobenzylidene malononitrile(CS), the principle for destroying CS by Incineration was analyzed, and the reaction products and equation of the incineration were determined. By incineration experiments, the major influencing factors on the incineration effect, such as single feed-in waste quantity, feed-in time interval, temperatures of the first and second firebox were discussed. Moreover, the optimized parameters for destroying CS by incineration equipment were determined. As a result, CS can be thoroughly destroyed by the special incineration equipment under the optimized parameters that the excess air coefficient is 2.0, the feed-in waste quantity is 400 g each time, the feed-in time interval is 3 min, the temperature of the first firebox is 750 ℃ and the second firebox is 1100 ℃.