Energetic fragment warhead was used to improve damage efficiency of weapons. The concept and characteristics of energetic fragment warhead were introduced. A kind of energetic fragment warhead containing Al/PTFE in the mass propotion of 30 to 70 was designed and prepared. The damage effects of the warhead on steel target with 2.5,10,20 mm were studied. Some damage tests were carried out. Results show that the 50 mm-caliber energetic fragment warhead can penetrate through 20 mm thick steel target and produce some plugging fragments, and prodacing evident overpressure in the region behind the target.