2,2-dinitro-1,3-propangdiol was synthesized using nitromethane and 38.5% formalin as raw matieral via two-step reaction, retraction and oxidative nitration, replacing the traditional oxidant of silver nitrate by sodium persulfate and potassium ferricyanide. The overall yield was more than 24.1% and purity was more than 97%. The effects of molar ratio of oxidated system, reaction temperature and reaction time on yields were investigated during oxidative nitration by orthogonal experiment.The optimum reaction conditions are as follows: K₃Fe(CN)₆, 0.1 mol, Na₂S₂O₈, 0.25 mol, reaction temperature, -5～0 ℃, reaction time, 4 hours.