The safety tests of 2,5-dipicryl-1,3,4-oxadiazole (DPO) and its application test in slapper detonator were studied. The slow cook-off test of DPO was conducted and its potential application for insensitive booster composition was discussed. Results show that DPO is an excellent booster explosive with good thermal stability and comparative shock wave sensitivity with HNS, and its basic physical, chemical and thermal performances are similar to that of hexanitrostibene (HNS). DPO is capable of passing the safety tests for booster explosive and used for in-line explosive as the permissive booster explosive. DPO is acted mildly at heat stimulating, and the performance of slow cook-off is excelled to booster.