Using a designed experimental device,explosion experiments of hydrocarbon with chlorine trifluoride in confined space were carried out,based on the analysis of the hydrocarbon and chlorine trifluoride reaction mechanism. The energy released from the reaction of hydrocarbon and chlorine trifluoride without oxygen was calculated based on experimental results. Results show that (1) The reaction of hydrocarbon and chlorine trifluoride accompanies an intense release of great deal of energy,so that part of the hydrocarbon is vaporized and dispersed,a violent deflagrating would be ignited once the vaporized hydrocarbon be mixed with the air. (2) The TNT equivalence of the explosion reaction of hydrocarbon and chlorine trifluoride without oxygen is about 1.8.