RDX was synthesized via nitrolysis of 1,3,5-triacylhexahydro-s-triazine with dinitrogen pentoxide（N₂O₅） in organic solvents(acetonitrile,nitromethane,chloroform,thtrachloromethane). The effects of organic media,dosage of N₂O₅,reaction temperature and reaction time on RDX yield have been investigated,which could be up to 63.5% and 75.2% respectively from 1,3,5-triacetylhexahydro-s-triazine and 1,3,5tripropionyllhexahydro-s-triazine with acetonitrile as solvent,and in the following reaction conditions: molar ratio of N₂O₅ to triazine 5:1,temperature 50 ℃,and the 1 h. IR,1H NMR,and elemental analysis confirmed the obtained product structure.