Uniform design was used to optimize the formula design of red phosphorus smoke agent. The four-component-formula and five-component-formula of red phosphorus smoke agent were obtained by regression analysis. The optimal formula were as follows: four-component-formula (coated red phosphorus 87%，KClO₄ 5.9%，Mg 2.5%，fluorine rubber 4.6%); five-component-formula (red phosphorus 68.8%，KNO₃ 14%，Mg 8.9%，chlorinated paraffin 3.8%，fluorine rubber 4.5%). Results show that the infrared transmittance in 8-14 μm of two formula of red phosphorus smoke agent were 12.81% and 11.92% when the relative humidity is 48% and mass concentration is 1 g·m^-3.