N-methyl-N′-nitroguanidine (MeNQ) and ammonium nitrate (AN) could consist a eutectic mixture, which could be formulated to a series of melt/cast intermolecular explosives. The synthesis of MeNQ was reviewed, and MeNQ/AN based melt/cast intermolecular explosives was introduced. MeNQ/AN binary eutectic mixture is a kind of intermolecular complex whose melting point is above 100 ℃, which leads to avoid ingress of much water during their melt pouring. The properties of MeNQ/AN based melt/cast explosives is only just lower than that of Composition B, but their sensitivity and cost overmatch that of Composition B.