A quantitative structure-property relationship (QSPR) model with 4 variables was established with electrotopological state (E-state) indices,and was used to analyze the impact sensitivity of 20 kinds of nitroaromatics. The correlation coefficient and standard deviation of the model are 0.929 and 0.079. The model possesses better reliability and correlation. Results show that the main structural factors influencing the impact sensitivity of m-nitroaromatics are the 4 sub-structures such as saCa，N，—CH₂— and —O—,which indicate that the electrical condition of atoms is an important factor affecting the impact sensitivity.