The physic-chemistry, detonation properties of GUDN(FOX-12) were reviewed, and its latest applications were introduced in detail. GUDN possesses high energy (approaches RDX), low sensitivity(approaches TATB), excellent thermal stability, non-hygroscopic, cold water insolubility, great gas production and innocuous. Moreover, GUDN is compatible with usual additives used for energetic materials. It is expected that GUDN is applicable in propellant, gas generating composition and insensitivity explosive with a broad prospect.