Six kinds of substituted piperazine were synthesized,and the structures of these compounds were identified by ¹HNMR、IR and elemental analysis. 4,10-dinitro-2,6,8,10-tetraoxa-4,10-diaza-tetrecyclo［5.5.0.0^5,90^3,11］-dodecane(TEX) was synthesized by nitrating these matrixs in different yields respectively, and the stability of the substituted piperazine explained why the yields were different.