The condensation reaction of 1,1,5-trihydro-octafluoro-pentanol (FOH-2) with epichlorohydrin (ECH) under the presence of NaOH to form 1,1,5-trihydro-octafluoro pentyl glycidylether(FGE-2) was investigated by using gas-liquid chromatograph. The reaction was found to be reversible and reach into equilibrium under the conditions of non-aqueous medium,mole ratio of reactants FOH-2/ECH/NaOH=1/3/1～1.2,post addition of FOH-2, reaction temperature of 50℃ and reaction time 4 to 5h.If the excess of NaOH was in the range of 5%～20%,the conversion of FOH-2 into FGE-2 would be higher than 90%. A satisfied result was also obtained in the case of post-adding ECH. The raw product was fractionated under reduced pressure and collected the fine FGE-2 at 68℃ and 266.6Pa with yield of 82% and epoxy value 0.3440～0.3470mol/100g.