Various methods have been tried to debenzulate hexabenzylhexaazaisowurtzitane (Ⅲ),but only by using hydrogenolysis at the presence of Pd/C catalyst and combining with acetylation in situ, a stable dibenzyltetraacetylhexaazaisowurtzitane (Ⅳ) can be obtained. (Ⅳ) is converted to dinitrosotetraacetylhexaazaisowurtzitane(Ⅴ),and then nitrated to dinitrotetraacetylhexaazaisowurtzitane(Ⅵ). (Ⅵ) is nitrated by different methods into the hexanitrohexaazaisowurtzitane with high yield. The structure of the product (Ⅵ) is identified by IR,MS(CI,EI),¹H-NMR,¹³ C-NMR and elemental analysis.