To investigate the effect of Al particle size on the quasi-static compression reaction and drop hammer impact sensitivity of aluminum-polytetrafluoroethylene (Al-PTFE), six types of Al-PTFE reactive material specimens with different Al particle size were prepared by molding sintering method and were comparatively tested by universal testing machine and drop hammer machine, and observed by high-speed photography instrument. The stress-strain curves and impact sensitivity data of different specimens were obtained, and the effect of Al particle size on the quasi-static compression mechanical properties and impact sensitivity of Al-PTFE was analyzed. Results show that in quasi-static compression test, the reaction of specimen with Al particle size less than 10 μm is occurred while the reaction of specimen with Al particle size larger than 10 μm does not occur. In drop hammer impact test, the reaction for six types of Al-PTFE specimens all is occurred. With the increase of Al particle size, the strength and sensitivity of specimens decrease, the toughness of specimens first increases and then decreases, reaching the maximum at 6-7 μm. The activation of Al-PTFE reactive material become more and more difficult to occur with the increase of Al particle size in lower strain rate range (10^-2-10² s^-1).